Albumin for Hypoalbuminemia in the Elderly albumin, a colloid, compared with crystalloid.3 The study found that albumin wasn't associated with higher morbidity and mortality in critically ill patients. These levels can drop if you are malnourished or have serious liver or kidney disease. Albumin levels can also be lowered by cancer, and they can get to very low levels if the cancer is advanced or spread around the body. Thus, the calcium level should be corrected in patients with low serum albumin levels, using the following formula: Corrected calcium (mg/dL) = measured total Ca (mg/dL) + 0.8 (4.0 - serum albumin . Methods . Having a blood albumin level of 4 g/dL means that one liter of your blood contains about 40 grams of albumin. The molecular weight of albumin is approximately 66 kDa, and it has a half-life of 21 days. Its prevalence ranges from 4% to 50% depending on whether they live at home or in hospice. Hemoglobin and hematocrit were . Treatment may include: blood pressure medication for people with kidney disease or heart failure. Chronic fatigue syndrome is a condition that affects more than a million people in the USA, more commonly women.It is characterized by debilitating fatigue, which is not relieved by resting, along with flu-like symptoms, enlarged lymph nodes, sore throat, and a "constantly fogged brain". In adult humans, albumin is the most abundant plasma protein with a concentration ranging from 35 to 50 g/L. We correlated the serum levels of albumin in 174 patients with GBS before and after standard high-dose IVIG therapy to clinical recovery. Many diseases or medical conditions may cause elevated protein blood levels (hyperproteinemia) or an imbalance of the ratio of albumin to globulins. It is also found in plant sources such as beans, nuts, and seeds. Amyloidosis is a rare disease that occurs when amyloid proteins are deposited in tissues and organs. Low serum 25(OH)D levels appear preventable and easily treated; there is an evident need for greater awareness to screen and thus prevent this condition. Recently, Miura et al. Hypoalbuminemia (or hypoalbuminaemia) is a medical sign in which the level of albumin in the blood is low. Chronic (long-term) inflammation or inflammatory disorders. Edema Treatment for Elderly. Albumin is a protein, found in animal sources such as meats, milk-products, and eggs. In the present study, we found a 30-day mortality rate of 4.3% for elderly patients after hip fractures, which was similar to a prospective study involving 728 patients (4.9%). So people may need to have a variety of tests to determine why there is not enough albumin in their blood. Malnutrition in the elderly is an underrecognized condition that is increasing in prevalence as the population ages. Low-grade albuminuria is associated with poor memory performance in the nondemented Chinese elderly with type 2 diabetes. Our study findings suggest that low serum albumin level, male sex, and total gastrectomy could be risk factors of severe postoperative complications in elderly gastric cancer patients. Patients with low serum albumin levels (<34 g/L), who made up 21% of the population, were more likely to die, had longer hospital stays, and were readmitted . A doctor will tailor treatment directly to the cause of the low protein. Hypoalbuminemia may be asymptomatic.Symptoms usually occur with very significant reduction in plasma albumin levels. In the present study, hypoalbuminemia was more frequent in the dead group (89.4 versus 50.4), and it was also found to be a significant risk factor (OR = 3.818). Your blood contains two classes of protein: albumin and globulins. The main goal of this study was to evaluate the effect of a mixture of fatty acids (FA) on the affinity of . The symptoms of hypoalbuminemia include peripheral edema, muscle weakness and cramps. From our hip fracture database, patients were consecutively included between January 2014 and December 2020. Treatment of low albumin levels (hypoalbuminemia) is based on correcting the underlying cause. lifestyle changes, particularly avoiding alcohol in people with liver disease. Patients with decreased levels of albumin, a protein made by the liver, can have a low anion gap. medications to manage chronic gastrointestinal disease or reduce inflammation in the body. In normal circumstances, albumin has a double function to maintain oncotic pressure and to transport endogenous or exogenous substances. There have been few data on the chemotherapy in elderly advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS), and usefulness of . This value, which compares the concentration of positively charged ions in the blood to negatively charged ions in the blood, can become abnormal by a number of metabolic derangements. In cases of an underlying hepatic pathology, ascites may occur.. Prealbumin helps carry thyroid hormones and vitamin A through your bloodstream. Therefore, surgeons should work carefully in cases of elderly gastric cancer patients with low preoperative serum albumin level and male sex. For patients with low albumin, it is necessary to evaluate the nutritional risk before surgery and formulate a nutritional treatment strategy. Albumin serum concentration is highly sensitive in the diagnosis of malnutrition in the hospitalized elderly, but it has low specificity . The normal adult value for calcium is 4.5-5.5 mEq/L. However, the ACA index does not include evaluation for functional status, which . 32 (6), 1975-1981. You can often treat hypoalbuminemia by raising your albumin levels back to normal. . Anticholinergic medications, benzodiazepines, and narcotics in high doses are common causes of drug induced delirium. The test measures both albumin and creatinine, a waste product of normal muscle breakdown. 22 An albumin level ≤2.0 g/dL has been associated with a 73% mortality rate in critically ill cancer patients. Since the potency of VCM is dependent on the free unbound form, albumin levels may have an influence on VCM treatment outcomes. Lean beef, pork, fish, chicken, and eggs are all good sources of protein. The best option for treating hypoalbuminemia is to address the underlying cause. Albumin provides the body with the protein needed to both maintain growth and repair tissues. What is chronic fatigue syndrome, and how is it connected to low globulin levels? If there is a fluid buildup in the chest, for instance, a chest tube may be inserted to relieve some of the buildup. Further analysis demonstrated that a lower GNRI score (<92.5) was linked to more unfavorable clinical features. In the elderly NSCLC patients with poor PS, serum albumin levels may help identify certain patient populations more likely to receive a survival benefit of systemic chemotherapy. Hypocalcemia is an electrolyte imbalance and is indicated by a low level of calcium in the blood. The elderly are more likely to suffer from hypoalbuminemia. Amyloid proteins are abnormal proteins that the body cannot break down and recycle, as it does with normal proteins. Low albumin in body can occur due to four main reasons. Albumin (as 20% or 25% solution) can be considered after paracentesis of <5 L at a dose of 8 g albumin/L of as-cites removed in patients with ACLF or high risk of post- paracentesis acute kidney injury. Serum TP concentrations in the AD, DLB, GPI, VD, and elderly patients with schizophrenia groups (all P < 0.001), as well as the serum albumin concentrations in the AD (P < 0.001), DLB (P = 0.009), GPI (P = 0.019), VD (P < 0.001), and elderly patients with schizophrenia (P < 0.001) groups were significantly lower than those of . Serum TP and Albumin Concentrations in the Cross-Sectional Study. A prealbumin blood test measures prealbumin levels in your blood. Patients with low albumin were older and admitted for a longer period of time than patients with a normal albumin, while patients with high albumin had a lower 30-day mortality, were younger and were admitted for a . A total of 410 elderly patients aged ≥65 years hospitalized for CHF were enrolled. In patients with SBP and an increased serum creatinine If it is due to anemia, you may receive drugs that stimulate the production of erythropoietin or supplement it. . Here are a few steps you can take: Eat a healthy low-sodium diet. It's also important to eat regularly to keep your energy levels up, so make sure to eat at least 3 meals a day and snack in-between. Your doctor will recommend that you. Conclusions: Low-dose albumin-bound paclitaxel plus tislelizumab might be an optional choice for elderly patients with metastatic NSCLC after the failure of platinum-based chemotherapy or targeted therapy. The peripheral edema and ascites usually occur as a result of low oncotic pressure owing to the hypoalbuminemia. Add foods with sources of vitamins, minerals, and antioxidants to your diet. The normal level of albumin in the blood is 3.5 g/dL to 5 g/dL. Abnormally low levels of globulins usually suggests a deficiency of antibodies due to the biggest portion of the globulins in the gamma fraction. Treatment for low albumin is a low sodium diet is recommended. Significant loss of muscle mass has been observed in elderly people with low albumin levels. Data were analyzed using two-way analysis of variance; the main effects on time, but not on group, and the time × group interactions were significant for . In patients with diabetes and hypertension, proteinuria is independently associated with all-cause death. Successful treatment of delirium depends on identifying the reversible contributing factors, and drugs are the most common reversible cause of delirium. Treatment may vary if a specific condition is causing your hypoalbuminemia. Hypoalbuminemia is a mortality prognostic factor in elderly people, whether they live in the community or they are in hospital or institutionalized. Hermida This level should be over the 1.0. Patients with low albumin were older and admitted for a longer period of time than patients with a normal albumin, while patients with high albumin had a lower 30-day mortality, were younger and were admitted for a . Hypoalbuminemia is proposed to result from increased capillary permeability and changes in albumin kinetics, necessary to allow substrates to reach areas . 6.2. VPA binds highly to albumin, resulting in free drug concentrations (5 to 15 mg/L) that are responsible for its therapeutic effect.2 Monitoring total VPA levels in patients with hypoalbuminemia could reveal seemingly subtherapeutic VPA lev-els, which could lead to unnecessary dos-age adjustments or drug toxicity. For patients with low albumin, it is necessary to evaluate the nutritional risk before surgery and formulate a nutritional treatment strategy. Eating a variety of colorful fruits and vegetables each day along with whole grains, beans, nuts and seeds is a strategy to lower inflammation. A retrospective analysis of patients with preoperative measurements of nutritional parameters who underwent intestinal surgery between April 2017 and August 2018 at our institution was performed. However, it is also essential to estimate the ratio of albumin to globulin when there are certain abnormalities. We studied the serum albumin level within 48 hours of hospitalization for acute illness to predict in-hospital death, length of stay, and readmission in 15 511 patients older than 40 years. Normal blood calcium levels are maintained through the actions of parathyroid hormone (PTH . There have been few data on the chemotherapy in elderly advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS), and usefulness of . The buildup of these deposits damages a person's organs and . Kwashiorkor, a severe form of protein-energy malnutrition, presenting in infants and children. The levels of albumin in a patient's blood can be affected by a number of diseases, including infection, heart failure, trauma, liver failure and kidney failure. Low 25(OH)D level was significantly associated with a high prevalence of falls in Japanese elderly women because of their inferior physical performance. The term malnutrition is often used to describe a deficiency in nutrition that . The serum albumin concentration is a prognostic factor in many lung diseases (24,25). If anemia is the cause and you have cancer, you may need a red blood cell transfusion. Crude 30-day mortality in patients with low albumin was 16.3% compared to 4.3% among patients with normal albumin (p<0.0001). These can be given as injections and take several weeks to . Postoperative Heart Transplant May be useful to treat anasarca in patients with albumin 3 gm/dL Dosing recommendation: 1. A low albumin level has been associated with mortality in the hospitalized elderly patients [8, 10, 11, 18, 21]. Perspective clinical studies with large sample size are needed to validate our results. Your health care professional may also order blood tests to check for low levels of protein in your blood and other problems linked to nephrotic syndrome. Normally, the total amount of these proteins in the blood falls between 6.0 and 8.3 grams per deciliter. People can have a low anion gap for a number of reasons. Figure 2A shows the electrophoretogram of a severe COVID- 19 patient who had a pre-albumin band, low albumin band, increased α 1, α 2 & γ bands and a β- γ bridging. Conformational changes in human serum albumin due to numerous modifications that affect its stability and biological activity should be constantly monitored, especially in elderly patients and those suffering from chronic diseases (which include diabetes, obesity, and hypertension). It is a sign of another underlying medical problem. A recent systematic review found that low pretreatment albumin levels were associated with increased mortality rates for multiple types of malignancies. Treatment. 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low albumin in elderly treatment

January 9, 2022by in construction of proportional counter

When to Contact Your Doctor or Health Care Provider: Severe diarrhea (greater than 5 stools in a day). It also helps regulate how your body uses energy. It is also used to treat low albumin levels in the blood (hypoalbuminemia) caused by: not enough albumin produced by the body (eg, malnutrition, burns, major injury, infections), excessive breakdown of albumin (eg, burns, major injury, pancreatitis), loss of albumin from . Its prevalence ranges from 4% to 50% depending on whether patients live at home or in hospice and whether they are bedridden or not. Treatment can also vary depending on a person's diet . Albumin for Hypoalbuminemia in the Elderly albumin, a colloid, compared with crystalloid.3 The study found that albumin wasn't associated with higher morbidity and mortality in critically ill patients. These levels can drop if you are malnourished or have serious liver or kidney disease. Albumin levels can also be lowered by cancer, and they can get to very low levels if the cancer is advanced or spread around the body. Thus, the calcium level should be corrected in patients with low serum albumin levels, using the following formula: Corrected calcium (mg/dL) = measured total Ca (mg/dL) + 0.8 (4.0 - serum albumin . Methods . Having a blood albumin level of 4 g/dL means that one liter of your blood contains about 40 grams of albumin. The molecular weight of albumin is approximately 66 kDa, and it has a half-life of 21 days. Its prevalence ranges from 4% to 50% depending on whether they live at home or in hospice. Hemoglobin and hematocrit were . Treatment may include: blood pressure medication for people with kidney disease or heart failure. Chronic fatigue syndrome is a condition that affects more than a million people in the USA, more commonly women.It is characterized by debilitating fatigue, which is not relieved by resting, along with flu-like symptoms, enlarged lymph nodes, sore throat, and a "constantly fogged brain". In adult humans, albumin is the most abundant plasma protein with a concentration ranging from 35 to 50 g/L. We correlated the serum levels of albumin in 174 patients with GBS before and after standard high-dose IVIG therapy to clinical recovery. Many diseases or medical conditions may cause elevated protein blood levels (hyperproteinemia) or an imbalance of the ratio of albumin to globulins. It is also found in plant sources such as beans, nuts, and seeds. Amyloidosis is a rare disease that occurs when amyloid proteins are deposited in tissues and organs. Low serum 25(OH)D levels appear preventable and easily treated; there is an evident need for greater awareness to screen and thus prevent this condition. Recently, Miura et al. Hypoalbuminemia (or hypoalbuminaemia) is a medical sign in which the level of albumin in the blood is low. Chronic (long-term) inflammation or inflammatory disorders. Edema Treatment for Elderly. Albumin is a protein, found in animal sources such as meats, milk-products, and eggs. In the present study, we found a 30-day mortality rate of 4.3% for elderly patients after hip fractures, which was similar to a prospective study involving 728 patients (4.9%). So people may need to have a variety of tests to determine why there is not enough albumin in their blood. Malnutrition in the elderly is an underrecognized condition that is increasing in prevalence as the population ages. Low-grade albuminuria is associated with poor memory performance in the nondemented Chinese elderly with type 2 diabetes. Our study findings suggest that low serum albumin level, male sex, and total gastrectomy could be risk factors of severe postoperative complications in elderly gastric cancer patients. Patients with low serum albumin levels (<34 g/L), who made up 21% of the population, were more likely to die, had longer hospital stays, and were readmitted . A doctor will tailor treatment directly to the cause of the low protein. Hypoalbuminemia may be asymptomatic.Symptoms usually occur with very significant reduction in plasma albumin levels. In the present study, hypoalbuminemia was more frequent in the dead group (89.4 versus 50.4), and it was also found to be a significant risk factor (OR = 3.818). Your blood contains two classes of protein: albumin and globulins. The main goal of this study was to evaluate the effect of a mixture of fatty acids (FA) on the affinity of . The symptoms of hypoalbuminemia include peripheral edema, muscle weakness and cramps. From our hip fracture database, patients were consecutively included between January 2014 and December 2020. Treatment of low albumin levels (hypoalbuminemia) is based on correcting the underlying cause. lifestyle changes, particularly avoiding alcohol in people with liver disease. Patients with decreased levels of albumin, a protein made by the liver, can have a low anion gap. medications to manage chronic gastrointestinal disease or reduce inflammation in the body. In normal circumstances, albumin has a double function to maintain oncotic pressure and to transport endogenous or exogenous substances. There have been few data on the chemotherapy in elderly advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS), and usefulness of . This value, which compares the concentration of positively charged ions in the blood to negatively charged ions in the blood, can become abnormal by a number of metabolic derangements. In cases of an underlying hepatic pathology, ascites may occur.. Prealbumin helps carry thyroid hormones and vitamin A through your bloodstream. Therefore, surgeons should work carefully in cases of elderly gastric cancer patients with low preoperative serum albumin level and male sex. For patients with low albumin, it is necessary to evaluate the nutritional risk before surgery and formulate a nutritional treatment strategy. Albumin serum concentration is highly sensitive in the diagnosis of malnutrition in the hospitalized elderly, but it has low specificity . The normal adult value for calcium is 4.5-5.5 mEq/L. However, the ACA index does not include evaluation for functional status, which . 32 (6), 1975-1981. You can often treat hypoalbuminemia by raising your albumin levels back to normal. . Anticholinergic medications, benzodiazepines, and narcotics in high doses are common causes of drug induced delirium. The test measures both albumin and creatinine, a waste product of normal muscle breakdown. 22 An albumin level ≤2.0 g/dL has been associated with a 73% mortality rate in critically ill cancer patients. Since the potency of VCM is dependent on the free unbound form, albumin levels may have an influence on VCM treatment outcomes. Lean beef, pork, fish, chicken, and eggs are all good sources of protein. The best option for treating hypoalbuminemia is to address the underlying cause. Albumin provides the body with the protein needed to both maintain growth and repair tissues. What is chronic fatigue syndrome, and how is it connected to low globulin levels? If there is a fluid buildup in the chest, for instance, a chest tube may be inserted to relieve some of the buildup. Further analysis demonstrated that a lower GNRI score (<92.5) was linked to more unfavorable clinical features. In the elderly NSCLC patients with poor PS, serum albumin levels may help identify certain patient populations more likely to receive a survival benefit of systemic chemotherapy. Hypocalcemia is an electrolyte imbalance and is indicated by a low level of calcium in the blood. The elderly are more likely to suffer from hypoalbuminemia. Amyloid proteins are abnormal proteins that the body cannot break down and recycle, as it does with normal proteins. Low albumin in body can occur due to four main reasons. Albumin (as 20% or 25% solution) can be considered after paracentesis of <5 L at a dose of 8 g albumin/L of as-cites removed in patients with ACLF or high risk of post- paracentesis acute kidney injury. Serum TP concentrations in the AD, DLB, GPI, VD, and elderly patients with schizophrenia groups (all P < 0.001), as well as the serum albumin concentrations in the AD (P < 0.001), DLB (P = 0.009), GPI (P = 0.019), VD (P < 0.001), and elderly patients with schizophrenia (P < 0.001) groups were significantly lower than those of . Serum TP and Albumin Concentrations in the Cross-Sectional Study. A prealbumin blood test measures prealbumin levels in your blood. Patients with low albumin were older and admitted for a longer period of time than patients with a normal albumin, while patients with high albumin had a lower 30-day mortality, were younger and were admitted for a . A total of 410 elderly patients aged ≥65 years hospitalized for CHF were enrolled. In patients with SBP and an increased serum creatinine If it is due to anemia, you may receive drugs that stimulate the production of erythropoietin or supplement it. . Here are a few steps you can take: Eat a healthy low-sodium diet. It's also important to eat regularly to keep your energy levels up, so make sure to eat at least 3 meals a day and snack in-between. Your doctor will recommend that you. Conclusions: Low-dose albumin-bound paclitaxel plus tislelizumab might be an optional choice for elderly patients with metastatic NSCLC after the failure of platinum-based chemotherapy or targeted therapy. The peripheral edema and ascites usually occur as a result of low oncotic pressure owing to the hypoalbuminemia. Add foods with sources of vitamins, minerals, and antioxidants to your diet. The normal level of albumin in the blood is 3.5 g/dL to 5 g/dL. Abnormally low levels of globulins usually suggests a deficiency of antibodies due to the biggest portion of the globulins in the gamma fraction. Treatment for low albumin is a low sodium diet is recommended. Significant loss of muscle mass has been observed in elderly people with low albumin levels. Data were analyzed using two-way analysis of variance; the main effects on time, but not on group, and the time × group interactions were significant for . In patients with diabetes and hypertension, proteinuria is independently associated with all-cause death. Successful treatment of delirium depends on identifying the reversible contributing factors, and drugs are the most common reversible cause of delirium. Treatment may vary if a specific condition is causing your hypoalbuminemia. Hypoalbuminemia is a mortality prognostic factor in elderly people, whether they live in the community or they are in hospital or institutionalized. Hermida This level should be over the 1.0. Patients with low albumin were older and admitted for a longer period of time than patients with a normal albumin, while patients with high albumin had a lower 30-day mortality, were younger and were admitted for a . Hypoalbuminemia is proposed to result from increased capillary permeability and changes in albumin kinetics, necessary to allow substrates to reach areas . 6.2. VPA binds highly to albumin, resulting in free drug concentrations (5 to 15 mg/L) that are responsible for its therapeutic effect.2 Monitoring total VPA levels in patients with hypoalbuminemia could reveal seemingly subtherapeutic VPA lev-els, which could lead to unnecessary dos-age adjustments or drug toxicity. For patients with low albumin, it is necessary to evaluate the nutritional risk before surgery and formulate a nutritional treatment strategy. Eating a variety of colorful fruits and vegetables each day along with whole grains, beans, nuts and seeds is a strategy to lower inflammation. A retrospective analysis of patients with preoperative measurements of nutritional parameters who underwent intestinal surgery between April 2017 and August 2018 at our institution was performed. However, it is also essential to estimate the ratio of albumin to globulin when there are certain abnormalities. We studied the serum albumin level within 48 hours of hospitalization for acute illness to predict in-hospital death, length of stay, and readmission in 15 511 patients older than 40 years. Normal blood calcium levels are maintained through the actions of parathyroid hormone (PTH . There have been few data on the chemotherapy in elderly advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS), and usefulness of . The buildup of these deposits damages a person's organs and . Kwashiorkor, a severe form of protein-energy malnutrition, presenting in infants and children. The levels of albumin in a patient's blood can be affected by a number of diseases, including infection, heart failure, trauma, liver failure and kidney failure. Low 25(OH)D level was significantly associated with a high prevalence of falls in Japanese elderly women because of their inferior physical performance. The term malnutrition is often used to describe a deficiency in nutrition that . The serum albumin concentration is a prognostic factor in many lung diseases (24,25). If anemia is the cause and you have cancer, you may need a red blood cell transfusion. Crude 30-day mortality in patients with low albumin was 16.3% compared to 4.3% among patients with normal albumin (p<0.0001). These can be given as injections and take several weeks to . Postoperative Heart Transplant May be useful to treat anasarca in patients with albumin 3 gm/dL Dosing recommendation: 1. A low albumin level has been associated with mortality in the hospitalized elderly patients [8, 10, 11, 18, 21]. Perspective clinical studies with large sample size are needed to validate our results. Your health care professional may also order blood tests to check for low levels of protein in your blood and other problems linked to nephrotic syndrome. Normally, the total amount of these proteins in the blood falls between 6.0 and 8.3 grams per deciliter. People can have a low anion gap for a number of reasons. Figure 2A shows the electrophoretogram of a severe COVID- 19 patient who had a pre-albumin band, low albumin band, increased α 1, α 2 & γ bands and a β- γ bridging. Conformational changes in human serum albumin due to numerous modifications that affect its stability and biological activity should be constantly monitored, especially in elderly patients and those suffering from chronic diseases (which include diabetes, obesity, and hypertension). It is a sign of another underlying medical problem. A recent systematic review found that low pretreatment albumin levels were associated with increased mortality rates for multiple types of malignancies. Treatment. Thus, in elderly people with functional disability and albumin <35 g/L it was found that malnutrition prevalence was 70%, whilst in autonomous elderly people with albumin concentrations >35 g/L, the . A total of 120 elderly essential hypertensive patients and 38 healthy elderly volunteers were involved. This article provides an approach for clinicians . Intravenous fluids may be required as well. According to the 2015 Egyptian Health Issues Survey, it has the highest prevalence of hepatitis C virus infection globally [].Moreover, the elderly population is increasing in our country, and, according to the latest estimate of the Central Agency for Public Mobilization and Statistics . As a result of low oncotic pressure and to transport endogenous or exogenous substances to transport endogenous exogenous! Abnormal proteins that the body can not break down and recycle, as it does normal! Pathology, ascites may occur surgeons should work carefully in cases of elderly cancer! 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Normally, the total protein content of plasma, with globulins making up most of the of... Dialysis treatment database, patients were consecutively included between January 2014 and December 2020 albumin and.... Aca index does not include evaluation for functional status, which lack of albumin is 66...

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low albumin in elderly treatment